28-Day Rule Does Not Apply
BPI is a drug manufacturer, so the 28-day rule does not apply to them. That guideline only applies to compounding pharmacies.
Beyond-Use Date (BUD)
Because BPI is a manufacturer, they assign a beyond-use date (BUD) based on validated stability and sterility data for the full duration of use - typically 9 to 12 months - even after the vial is punctured.
Proper Storage and Use
The vials are designed and tested for extended use as long as you:
Store your vial refrigerated between uses
Use a new sterile needle for each injection
Do not expose the vial to contamination
Safety and Effectiveness
If you follow these instructions, your vial remains safe and effective for the full intended duration of your treatment plan.