Enclomiphene is the active isomer of clomiphene citrate. It works by signaling the body to increase its own natural testosterone production while maintaining the hormonal pathway involved in fertility. Unlike traditional testosterone replacement therapy (TRT), which provides external testosterone, enclomiphene supports your body’s internal testosterone-producing process.

Enclomiphene influences the hypothalamic–pituitary–gonadal axis, encouraging the body to produce more luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones signal the testes to produce testosterone. This approach allows testosterone levels to increase while keeping the reproductive system active.

Enclomiphene may be an option for men who:

Eligibility is always determined by a licensed clinician based on your medical history, symptoms, and lab results.

Enclomiphene may not be appropriate for individuals with certain medical conditions or those who are better suited for a different therapy. A clinician will review your labs and health history to determine whether enclomiphene is a safe and appropriate option.

People typically begin the protocol with low testosterone levels that improve over time. Many notice changes in energy, motivation, strength, mood, or sexual health as their testosterone rises, but the exact experience varies. Some individuals see earlier shifts, while others see more gradual progress. Your clinician will review your labs and symptoms over time to evaluate whether the protocol is working for you.

Your clinician makes treatment decisions using a combination of:

Personalized adjustments, if appropriate, are based on your body’s response and safety considerations.

To ensure the protocol remains safe and effective, clinicians may order follow-up labs on a periodic basis. These labs help evaluate your hormonal response and guide any potential adjustments.