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Side Effects & Safety of Enclomiphene

Updated over 2 weeks ago

Enclomiphene is designed to support your body’s natural testosterone production. Like any medication, it may cause side effects for some people. Most are mild and temporary, but experiences vary. Your clinician will evaluate whether enclomiphene is appropriate for you based on your medical history, symptoms, and lab results.


Commonly Reported Experiences

Some people report changes as their hormone levels shift, including:

  • Mood variability

  • Mild headaches

  • Changes in energy or sleep patterns

  • Temporary changes in libido

These experiences can occur as your body adjusts. They often improve over time.


Less Common Effects

Less common effects may include:

  • Temporary increases in irritability or emotional sensitivity

  • Mild digestive changes

  • Short-term fluctuations in appetite or weight

These are usually not serious but should be reported if they persist or feel unusual.


Impact on Fertility

Enclomiphene supports the hormonal signals involved in sperm production, which is why it is often chosen by people who want to maintain fertility. However, fertility is influenced by many factors, and individuals respond differently. Your clinician can discuss high-level considerations, but they cannot provide individualized predictions or instructions through the Help Center.


Hair and Skin

Some individuals ask whether enclomiphene affects hair or skin. Testosterone and related hormones can influence these areas differently from person to person. If you notice changes that concern you, reach out to your clinician so they can review your specific situation.


Serious or Concerning Symptoms

If you experience:

  • Severe or worsening mood changes

  • Chest pain

  • Shortness of breath

  • Severe headaches

  • Visual changes

  • Any symptom that feels significantly out of the ordinary

you should seek urgent medical care. For non-urgent questions or changes, you can message your clinician through your patient portal.


How Safety Is Monitored

Your clinician uses:

  • Follow-up labs

  • Symptom check-ins

  • Your medical history

  • Any reported side effects

to evaluate whether the protocol remains appropriate. Any adjustments to your plan, if clinically indicated, are personalized to your response and safety needs.

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