GLP-1 medications used in the Weight Loss Protocol are well-studied and have been shown to support weight loss and metabolic health. Like all medications, they may cause side effects for some people. Your clinician will determine whether this treatment is safe and appropriate for you based on your health history, symptoms, and lab results.
Common Side Effects
Many side effects are related to how GLP-1 medications influence digestion and appetite. These may include:
Mild nausea
Diarrhea or loose stools
Constipation
Reduced appetite
Occasional stomach discomfort
These effects often improve as your body adjusts. If they persist or become uncomfortable, you can message your clinician for guidance.
Less Common Effects
Some individuals may notice:
Fatigue
Bloating
Mild headaches
Changes in taste or food preferences
These experiences vary and are not necessarily signs of a problem. Your clinician can help assess what’s typical for you.
Serious or Concerning Symptoms
Although rare, certain symptoms may require prompt medical attention. Seek urgent care if you experience:
Severe abdominal pain
Persistent vomiting
Signs of dehydration
Shortness of breath
Chest pain
Any symptom that feels severe, escalating, or unusual for your baseline
Report non-urgent concerns through your patient portal so your clinician can review and determine next steps.
Managing Side Effects
If you experience side effects, your clinician may discuss high-level strategies to help you feel more comfortable. Any treatment decisions or adjustments depend on your health history, your current medication plan, and how you are responding.
Long-Term Safety Monitoring
Your clinician monitors your progress over time to ensure the protocol remains safe and appropriate. This may include:
Periodic lab work
Symptom check-ins
Review of your overall health status
Assessment of how you’re responding to treatment
All decisions are made by your clinician based on a combination of clinical judgment, your experience, and your lab results.
Medication Quality
Maximus works with pharmacy partners that source the base form of semaglutide and tirzepatide. This ensures the active ingredient matches what is used in clinical studies and avoids untested variants that may differ in safety or effectiveness.