The adverse effects of enclomiphene have been extensively studied during phase II and phase III clinical trials. The drug is generally well tolerated with side-effects occurring relatively rarely.

Headache (was observed in 3.3% of patients)
Common Cold (was observed in 1.7% of patients)
Nausea (was observed in 2.1% of patients)
Hot flush (was observed in 1.7% of patients)
Diarrhea (was observed in 1.9% of patients)
Joint pain (was observed in 1.2% of patients)
Dizziness (was observed in 1% of patients)