In published clinical trials on enclomiphene, adverse ocular effects were only observed with higher dosages, and the overall prevalence was less than placebo, which suggests enclomiphene itself is unlikely to be causing the effect (e.g. 3 out of 4 people already have floaters, but don’t notice them until they become hyper vigilant from reading online forums).

In our own clinical trial of 1250 patients, only 1 reported ocular effects, which was confounded by prior use of Clomid. Most of the warnings you read online are from people taking fake enclomiphene that is actually Clomid, which has an extra estrogen agonist with known ocular effects. In short, ocular effects are rare, often due to placebo and other factors, and reversible upon reducing the dosage or discontinuation. Overall, enclomiphene in appropriate dosages and supervised medically is safe and effective for long-term use.