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All CollectionsEP Protocol (Enclomiphene + Pregnenelone)
Are there eye concerns or heart concerns with enclomiphene, like clomiphene (clomid)?
Are there eye concerns or heart concerns with enclomiphene, like clomiphene (clomid)?

Enclomiphene/Pregnenolone

Mickler avatar
Written by Mickler
Updated over 5 months ago

We are not aware of any reports of significant visual or cardiac side effects with enclomiphene, as it lacks the zuclomiphene isomer that clomiphene contains, which is likely responsible for these issues.

In contrast, enclomiphene is generally well tolerated with side effects occurring relatively rarely (listed on our website). Of note, researchers noted “overall, there was no evidence of drug toxicity and rates of adverse events were not significantly different from placebo.”

Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-65. https://pubmed.ncbi.nlm.nih.gov/31063005/

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