Enclomiphene will likely increase your serum estradiol levels, so low estradiol-associated symptoms do not apply here (e.g. joint pain associated with aromatase inhibitors). Because the estrogen receptors are also being selectively blocked in particular areas like the brain and breast tissues, higher serum estradiol levels do not cause common high estrogen side effects (e.g. mood issues or gynecomastia associated with TRT).